Change is possible with individualized dosing for cataplexy and/or EDS in narcolepsy

XYWAV is a liquid taken twice nightly.

Woman with yellow butterfly wings is smiling while having a hand on a clothing rack outside of a store

Change is possible with individualized dosing

Finding the right dose takes time

When you start taking XYWAV, your doctor may adjust or titrate your dosage each week until you reach a dose that works best for you. During this time, it’s not uncommon to experience some side effects. Make sure you tell your doctor.

Some ways your doctor can tailor your XYWAV treatment includes adjusting:

The timing between your first and second doses (2.5 to 4 hours after the first dose)

Your total nightly dose

How much medicine you take with your first and second dose

With XYWAV, your doctor can adjust the dose of your medication at increments as low as 0.25 g

Recommended starting dose:

4.5 g divided into 2 doses (at bedtime and 2.5 to 4 hours later)

Recommended maximum dose:

9 g divided into 2 doses

Dosing increments:

0.25 g–1.5 g per night per week

Instructions for proper preparation and dosing of XYWAV

When you receive your first shipment of XYWAV, be sure to read the Instructions for Use (IFU) in the Medication Guide for detailed instructions on preparing and taking XYWAV. You'll also receive the XYWAV and XYREM (sodium oxybate) oral solution REMS Patient Quick Start Guide along with your medication and detailed preparation and dosing instructions. Here's an overview of what you'll need to know to take XYWAV:

Taking XYWAV twice nightly

Before bedtime

Prepare both of your doses and put them in a safe and secure place
Before you take XYWAV, your doses should be mixed with approximately ¼ cup of water per dose in the empty pharmacy containers provided for you

At bedtime

Take your first dose while in bed and lie down immediately
- XYWAV can cause sleep very quickly without making you feel drowsy
- Some people fall asleep within 5 minutes, and most fall asleep within 15 minutes (though the time it takes any individual to fall asleep may vary from night to night)

2.5 to 4 hours (after bedtime)

You must wake up to take the second dose 2.5 to 4 hours after your first, as instructed by your doctor
- You may want to set an alarm clock to make sure you wake up to take the second dose
If you are prescribed XYWAV twice nightly and miss the second dose, skip it
- Never take 2 doses of XYWAV at one time
You should remain in bed after taking each dose of XYWAV

It's important to remember…

Wait at least 2 hours after eating before taking XYWAV
Prepared doses should be taken within 24 hours after mixing
Store XYWAV in a safe place, away from children and pets

What to expect when transitioning to XYWAV from XYREM

Your doctor is recommended to initially prescribe XYWAV at the same dose and regimen as your XYREM treatment
Take XYWAV exactly as your doctor instructs. If needed, your doctor may adjust your dosage or dosing routine
Your doctor won't need to re-enroll you in XYWAV and XYREM REMS, since you're already enrolled

Helpful reminders for caregivers

For children, give the first XYWAV dose at bedtime or after an initial period of sleep, while your child is in bed and have them lie down immediately. Give the second XYWAV dose 2½ to 4 hours after the first XYWAV dose. You may want to set an alarm clock to make sure you wake up to give the second XYWAV dose. Your child should remain in bed after taking the first and second doses of XYWAV.

XYWAV Medication Guide and Instructions for Use

Read the Medication Guide and Instructions for Use for detailed instructions on preparing and taking XYWAV.

Download English Version

Download Spanish Version

Learn about Brooke's nighttime routine

"Having a consistent nighttime routine has been really important to my success on XYWAV."
—Brooke, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.