A man discussing his sodium intake and his narcolepsy symptoms

It‘s time to address the high‑sodiumelephant in the room

Talk to your doctor about low-sodium* XYWAV.

XYWAV is thought to work during sleep to help improve symptoms of cataplexy and excessive daytime sleepiness (EDS) during the day.^†

*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.

^†The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

XYWAV is a prescription medicine used to treat the following symptoms in people 7 years of age or older with narcolepsy: sudden muscle weakness triggered by strong emotions (cataplexy) and excessive daytime sleepiness (EDS).

Did you know that people with narcolepsy are at an increased risk of certain cardiovascular conditions?

Compared to the general population, people with narcolepsy have:

Compared to the general population,
people with narcolepsy have:

^‡Odds ratio.
^§Based on an interview-based study of 320 people with narcolepsy to 1464 people without narcolepsy matched for age, sex, and body mass index.
^‖Based on an analysis of 9312 people with narcolepsy and 46,559 people without narcolepsy matched by age, sex, geographic region, and payer who had continuous insurance coverage between years of 2006 and 2010.
^¶Hazard ratio.
^#Based on an analysis of 34,562 people with narcolepsy and 100,405 people without narcolepsy matched by presence of relevant health conditions, including sleep apnea and diabetes.

Learn more about how some risk factors for cardiovascular diseases, like excessive sodium intake, are modifiable.

NARCOLEPSY & RISK FACTORS

Consider sodium intake in medicine and your heart health

XYWAV is the first and only low-sodium^¶ oxybate approved by the FDA to help treat cataplexy and/or EDS in narcolepsy for patients 7 years of age and older.
Learn more about why choosing XYWAV over high-sodium oxybates can help reduce your sodium intake, a modifiable factor for cardiovascular disease.

SODIUM AND XYWAV

^¶XYWAV contains 131 mg of sodium at the maximum recommended nightly dose. At the same dose, high-sodium oxybates contain ~1640 mg of sodium.

The XYWAV Coupon Program

Pay as little as $5 for XYWAV.

Jazz Pharmaceuticals reserves the right to terminate or modify this program at any time with or without notice. Other Terms and Conditions apply.

Savings & Support From the Start

If your doctor prescribes XYWAV, JazzCares offers several support programs to help patients with the cost of treatment, so you can start XYWAV as soon as possible.

SHOW ME HOW TO SAVE

Hear from real patients taking XYWAV

Watch videos from people living with narcolepsy and learn how they fit XYWAV treatment into their lives.

Watch patient stories

myWAV is a 24/7 online tool for XYWAV® resources and support

myWAV: Individualized support at your fingertips

If you've been prescribed XYWAV, download the free myWAV app today and unlock smart support. Watch this video to find out more, and download the app below.

All third‑party product, company names and logos are trademarks^™ or registered^® trademarks and remain the property of their respective holders.

IMPORTANT SAFETY INFORMATION

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.