What is XYWAV?

The first and only FDA‑approved treatment for adults with Idiopathic Hypersomnia (IH)

You’ve tried different ways to manage your IH—it may be time to try XYWAV

XYWAV helps manage multiple symptoms of IH such as:

Excessive daytime sleepiness

Sleep inertia

Severe grogginess or confusion when waking up regardless of how much sleep you get or how many alarms you set—feeling disoriented, irritable, or even clumsy when waking up and for hours afterwards

Cognitive impairment

Difficulty focusing, trouble thinking clearly, or memory problems due to excessive daytime sleepiness—often described as “brain fog”

Long sleep time

Ability to sleep for many hours of the day—
sometimes for 11 hours or more

XYWAV is different

Unlike stimulants and wake-promoting agents that are taken during the day, XYWAV is different—it's taken at night.

With twice‑ or once‑nightly options for adults with IH

Your doctor will work with you to find the right dose. Please click here to learn more about XYWAV dosing.

Explore the facts and fictions of managing IH

What do you know about managing IH? Click through the flashcards on the side to see how much you know and how treatment with XYWAV may help you.

Stimulants are the
only option to treat IH

false

There's another way to manage IH: XYWAV, the first and only FDA-approved treatment for adults with IH. Unlike stimulants and wake-promoting agents that are taken during the day, XYWAV is taken at night to help treat multiple symptoms of Idiopathic Hypersomnia, such as excessive daytime sleepiness, sleep inertia (severe grogginess or confusion when waking up), long sleep time, and cognitive impairment.

I can't try XYWAV if I've already tried taking stimulants or wake-promoting agents.

false

Some patients in the clinical trial continued taking their stimulants or wake-promoting agents while also taking XYWAV.

XYWAV must be taken twice a night for patients with IH.

false

Adults with IH can take XYWAV once or twice nightly (at bedtime and again 2.5 to 4 hours later). Dosing with XYWAV can be individualized, so you can work with your doctor to find the dosing schedule that works for you. Check out the Taking XYWAV page to learn more.

I won't have support options to help me get and pay for XYWAV.

false

More than 90% of people who have health insurance through their employer or purchased through an exchange (also known as commercial insurance) are typically covered. These people who have commercial insurance for XYWAV may pay as little as $5 per prescription. Financial assistance options are available through JazzCares for eligible patients.

Watch the video to learn about Jennie's journey with her IH symptoms

XYWAV is FDA-approved to help treat people with IH like Jennie. Watch her story

Real patient compensated for their time. Individual results may vary.

“When I was first diagnosed with IH, my treatment plan focused on excessive daytime sleepiness, but I also needed help managing my other IH symptoms. That’s when my doctor told me about XYWAV.”

—Casey, XYWAV IH Ambassador

Real patient compensated for their time. Individual results may vary.

How does XYWAV work?Although the exact way XYWAV works is unknown, it is thought to work during sleep to help with IH symptoms.

See Study Results for IH

Get information and stay supported

From learning more about your IH, to helping start the conversation with your doctor, and exploring XYWAV as a treatment option—take charge of your journey with support every step of the way.

IMPORTANT SAFETY INFORMATION

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.