What is XYWAV?

XYWAV is the only low-sodium* oxybate and the first and only FDA-approved treatment for adults with Idiopathic Hypersomnia.

*XYWAV contains 131 mg of sodium at the 9-g nightly dose.

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XYWAV can help manage nighttime and daytime symptoms of IH, such as:

EDS

Excessive daytime sleepiness

Sleep inertia

Sleep inertia

Cognitive impairment

Cognitive impairment

Long sleep time

Long sleep time

Unlike stimulants that are taken during the day, XYWAV is different. It's taken at night.

XYWAV is thought to work during sleep to help treat symptoms of IH. The exact way XYWAV works is unknown.

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XYWAV can be taken in addition to daytime medication like stimulants. Be sure to talk to your doctor about any medications you are taking or plan to take.

Explore the facts and myths of managing IH

What do you know about managing IH? Take a moment to answer a few quick questions to better understand how XYWAV may help you.

Stimulants are the only option to treat IH

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There's another way to manage IH: XYWAV, the only low-sodium* oxybate that's FDA-approved for adults with Idiopathic Hypersomnia. Unlike stimulants and wake-promoting agents that are taken during the day, XYWAV is taken at night. XYWAV has been studied across multiple symptoms of IH, such as excessive daytime sleepiness, sleep inertia (severe grogginess or confusion when waking up), long sleep time, and cognitive impairment.

*XYWAV contains 131 mg of sodium at the 9-g nightly dose.

XYWAV cannot be taken in combination with stimulants or wake-promoting agents

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Did you know nearly 3 out of 5 patients (57%) in the phase 3 clinical trial continued taking their daytime stimulants or wake-promoting agents while starting XYWAV?

XYWAV can be taken once or twice nightly for patients with IH

That's correct Did you know?

Adults with IH can take XYWAV once or twice nightly (at bedtime and again 2.5 to 4 hours later) as prescribed. Dosing with XYWAV can be individualized, so you can work with your doctor to find the right dosing schedule that works for you. Check out Taking XYWAV to learn more.

There are no support options available to help patients get and pay for XYWAV

That's correct Here's what to know

More than 90% of people who have health insurance through their employer or purchased through an exchange (also known as commercial insurance) are typically covered. These people who have commercial insurance for XYWAV may pay as listtle as $0 per prescription. Financial assistance options are available through JazzCares^® for eligible patients.

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Your sodium intake matters

Consuming too much sodium is a risk factor for cardiovascular disease. In addition to food and drinks, sodium may also come from certain medications. XYWAV is the only low-sodium oxybate.

A 9g nightly dose of XYWAV has ~1200 mg less sodium than the ideal 1500mg sodium intake limit for most adults and ~1300 mg less sodium than the sodium content of an order of four large french fries

A 9g nightly dose of XYWAV has ~1200 mg less sodium than the ideal 1500mg sodium intake limit for most adults and ~1300 mg less sodium than the sodium content of an order of four large french fries

At the dose of 9 g/night, XYWAV has ~1300 mg less sodium than the ideal daily sodium intake limit for most adults

*Based on an average of 380 mg of sodium in 1 large serving of French fries according to a 2012 U.S. Department of Agriculture analysis of 3 fast-food chains.

See how XYWAV helps Jennie manage her IH

“I noticed after trying XYWAV that I felt more awake, and I no longer had the overwhelming desire to go back to sleep for 2 to 3 more hours like I normally did.”
—Jennie, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.

Jennie, a XYWAV patient with Idiopathic Hypersomnia, discusses her journey with XYWAV for Idiopathic Hypersomnia

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Find out how XYWAV was studied

See Study Results

XYWAV (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

the following symptoms in people 7 years of age or older with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.