Managing IH

Are you managing the multiple symptoms of IH?

Excessive daytime sleepiness: not the only symptom of IH.

Other symptoms include:

Sleep inertia

Severe grogginess or confusion when waking up regardless of how much sleep you get or how many alarms you set—feeling disoriented, irritable, or even clumsy when waking up and for hours afterwards

Cognitive impairment

Difficulty focusing, trouble thinking clearly, or memory problems due to excessive daytime sleepiness—often described as “brain fog”

Long sleep time

Ability to sleep for many hours of the day—
sometimes for 11 hours or more

Non-restorative sleep

Not feeling rested when you wake up, despite sleeping a typical (or more than typical) amount each night

Long, unrefreshing naps

Not feeling refreshed or better after napping (may even feel worse)

Are IH symptoms impacting you more than you realize?

Some of the things you've been experiencing may be symptoms of IH. Explore the statements below to see if you'd like to take the next step to manage your IH.

Excessive daytime sleepiness is the only symptom of IH.

false

IH is a 24-hour condition with multiple symptoms including excessive daytime sleepiness, sleep inertia (severe grogginess or confusion when waking up), cognitive impairment (brain fog), long sleep time, and unrefreshing sleep.

Feeling extremely groggy while trying to wake up after sleep is no different than daytime sleepiness.

false

The severe and lasting grogginess and confusion you feel when you try to wake up could be sleep inertia, a symptom of IH that can make it feel impossible to get out of bed.

If you have IH, getting more sleep will make you feel fully rested and energized throughout the day.

false

With IH, no matter how much you sleep, it’s often not refreshing. Similar to sleep at night, daytime naps may also be long (often >1 hour) and are unrefreshing as well.

There is no FDA-approved medication to treat IH.

false

XYWAV is the first and only FDA-approved medication to treat IH in adults. XYWAV has been studied across multiple symptoms of IH such as excessive daytime sleepiness, sleep inertia, cognitive impairment, and long sleep time.

Take this quiz to evaluate your IH experience.Use the results to take the next step—talking with your doctor or finding a doctor to treat your IH.

Take The Quiz

If you have trouble getting up in the morning, problems focusing, and never feel rested no matter how much sleep you get, it’s time to talk to your doctor.

Find Your Provider

Get information and stay supported

From learning more about your IH, to helping start the conversation with your doctor, and exploring XYWAV as a treatment option—take charge of your journey with support every step of the way.

IMPORTANT SAFETY INFORMATION

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.